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Identification of Host Pathways Targeted by Bacterial Effector Proteins using Yeast Toxicity and Suppressor Screens
Published on: October 25, 2019
Interactions of bacterial effector proteins with host proteins
Seema Mattoo1, Yvonne M Lee, Jack E Dixon
1The Howard Hughes Medical Institute, Leichtag Biomedical Research Building, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0721, USA.
Current Opinion in Immunology
|July 31, 2007
Summary
Pathogenic bacteria use novel strategies like acetylation and lytic modifications to block host cell signaling, creating niches for survival. This review details common host targets of these bacterial manipulation mechanisms.
Area of Science:
- Microbiology
- Cell Biology
- Biochemistry
Background:
- Pathogenic bacteria employ sophisticated mechanisms to survive within host organisms.
- Manipulation of host cell signaling pathways is crucial for bacterial pathogenesis and establishing replicative niches.
Purpose of the Study:
- To review novel bacterial strategies for manipulating host cell signaling pathways.
- To highlight common host proteins and signaling cascades targeted by pathogens.
Main Methods:
- Literature review of recent scientific publications.
- Analysis of bacterial mechanisms affecting host cell signaling.
- Identification of host targets of bacterial manipulation.
Main Results:
- Bacteria utilize modifications beyond phosphorylation, including acetylation, beta-elimination, and lytic events, to control host signaling.
- These bacterial modifications can irreversibly block host signaling pathways.
- Specific host proteins and signaling cascades are frequently targeted by various pathogens.
Conclusions:
- Pathogenic bacteria have evolved diverse and potent mechanisms to subvert host cell functions.
- Understanding these bacterial manipulation strategies is key to developing new therapeutic interventions.
- Bacterial interference with host signaling represents a significant area of research in infectious disease.
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