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Interleukin 1 production by monocytic leukemia cells and its possible role in coagulation abnormalities
1Division of Hemopoiesis, Jichi Medical School, Tochigi, Japan.
Leukemia Research
|January 1, 1991
Abstract:
Interleukin 1 (IL-1) production by leukemic cells was studied in 16 patients with myelocytic or monocytic leukemia. Leukemic cells from the patients with monocytic leukemia showed higher IL-1 production than those with myelocytic leukemia. Subclinical coagulation abnormalities were observed more frequently in patients with higher IL-1 producing monocytic leukemia. It is suggested that IL-1 from leukemic cells might play important roles in the establishment of these clinical features. Such observations might be of value in the understanding of the pathophysiology of leukemia-associated paraneoplastic phenomena.