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Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter
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Reduction of Iatrogenic Atrial Septal Defects with an Anterior and Inferior Transseptal Puncture Site when Operating the Cryoballoon Ablation Catheter

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The presence of Down syndrome is not a risk factor in complete atrioventricular septal defect repair

Ruediger Lange1, Thomas Guenther, Raymonde Busch

  • 1Department of Cardiovascular Surgery, German Heart Center, Clinic at the Technical University, Munich, Germany.

The Journal of Thoracic and Cardiovascular Surgery
|July 31, 2007
PubMed

Insights

Down syndrome (DS) patients with complete atrioventricular septal defect (CAVD) have higher pulmonary pressures but similar surgical outcomes to non-DS patients. Early repair is recommended for DS patients due to potential pulmonary vascular disease.

Area of Science:

  • Cardiology
  • Pediatric Surgery
  • Genetics

Background:

  • Complete atrioventricular septal defect (CAVD) is common in Down syndrome (DS).
  • Understanding the impact of DS on CAVD outcomes is crucial for surgical planning.

Purpose of the Study:

  • To evaluate the influence of Down syndrome on the morphology, surgical management, and mortality of patients with complete atrioventricular septal defect.

Main Methods:

  • Retrospective analysis of 476 patients with CAVD who underwent surgery between 1974 and 2005.
  • Comparison of outcomes between patients with (Group D) and without (Group ND) Down syndrome.

Main Results:

  • Patients with Down syndrome showed higher preoperative pulmonary artery pressure and resistance.
  • No significant differences in operative strategy or timing of repair were observed.
  • Long-term survival was comparable, but left atrioventricular valve reintervention was less frequent in Down syndrome patients.

Conclusions:

  • Down syndrome is not a risk factor for surgical repair of CAVD.
  • Early primary repair (within 6 months) is advised for DS patients due to early pulmonary vascular disease.
  • Children without Down syndrome require more frequent left atrioventricular valve reinterventions long-term.
Abstract

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