Spectrophotometric determination of rosuvastatin calcium in tablets

Rosuvastatin calcium is a synthetic lipid lowering agent which is used in hypercholesterolemia. It is a selective and competitive inhibitor of HMG-CoA reductase. In this study a simple, rapid and reliable spectrophotometric method was developed for the determination of rosuvastatin calcium in pharmaceutical preparations. The solutions of standard and pharmaceutical samples were prepared in methanol. 243 nm was chosen for measuring absorbances of rosuvastatin calcium. The developed method was validated with respect to linearity range, limit of detection and quantitation, accuracy, precision, specificity and ruggudness. The linearity range of the method was 1.0-60.0 microg mL(-1). The limit of detection was 0.33 microg mL(-1). The developed and validated method was applied to the determination of rosuvastatin calcium in pharmaceutical preparations.