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Related Experiment Video

Updated: Jul 13, 2026

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

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Published on: June 23, 2023

Alcohol-induced anaphylaxis to grapes.

E Alcoceba Borràs¹, E Botey Faraudo, P Gaig Jané

¹Allergy Unit, University Hospital Joan XXIII, Tarragona, Spain.

Allergologia Et Immunopathologia

|August 1, 2007

Summary

Alcohol can trigger severe allergic reactions to grapes, leading to anaphylaxis. This study found no unique grape allergens when alcohol is consumed concurrently, suggesting a cofactor effect.

Area of Science:

Food allergy research
Immunology
Clinical case studies

Background:

Grape allergy is rare, but reactions to grapes, wine, and exercise-induced grape allergy have been documented.
Alcohol consumption has been noted as a potential cofactor in allergic reactions.

Observation:

An 18-year-old woman experienced anaphylaxis linked to consuming grapes with alcoholic beverages.
She tolerated grapes alone but reacted when combined with alcohol.
Skin prick tests and oral challenges confirmed reactions to grapes and champagne.

Findings:

Immunological studies, including SDS-PAGE and IgE immunoblotting, were conducted on patient sera.
No distinct grape allergens were identified when alcohol acted as a cofactor.
Allergens implicated in alcohol-induced anaphylaxis to grape were similar to those in non-alcohol-induced grape allergy.

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Published on: November 15, 2024

Implications:

This case highlights alcohol as a cofactor in grape-induced anaphylaxis.
Further research is needed to understand the mechanisms behind alcohol's role in food allergies.
Clinicians should consider alcohol consumption when evaluating patients with unexplained food-induced allergic reactions.