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Stratum basale, also known as the stratum germinativum, is the deepest layer of the epidermis. It is composed of a single layer of actively dividing cells called basal cells or basal keratinocytes. These cells constantly undergo cell division to replenish the upper layers of the epidermis. Additionally, melanocytes, which...

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Related Experiment Video

Updated: Jul 13, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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[Palmar filiform parakeratotic hyperkeratosis without underlying malignancy].

L Pérez-Pérez¹, C Peteiro, D Sánchez-Aguilar

¹Servicio de Dermatología, Complejo Hospitalario Universitario, Facultad de Medicina, Santiago de Compostela, A Coruña, España. mejaime@usc.es

Actas Dermo-Sifiliograficas

|August 1, 2007

Summary

Filiform hyperkeratosis (FH) is a rare skin condition presenting as keratotic spicules. This case highlights exclusive palmar involvement in an elderly patient, emphasizing the need to rule out underlying diseases despite no malignancy found.

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

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Area of Science:

Dermatology
Histopathology

Background:

Filiform hyperkeratosis (FH) is a rare skin condition characterized by keratotic spicules.
Its association with neoplasms is debated, and it's not a well-defined paraneoplastic disorder.

Observation:

A 72-year-old patient presented with a three-month history of bilateral palmar lesions.
No other body surface lesions or abnormal findings from complementary exams were noted.

Findings:

Histopathological examination revealed parakeratotic columns, a reduced granular layer, and mild dermal inflammation.
The case presented exclusive palmar involvement without underlying malignancy.

Implications:

FH may be distinct from porokeratoses due to unique clinical and histological features.
Despite unclear links to neoplasms, thorough investigation for underlying conditions is recommended for FH cases.