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Updated: Jul 13, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
Published on: August 9, 2024
[Acral keratoses and inverted follicular keratosis presenting Cowden disease]
A Larumbe1, M E Iglesias, J J Illarramendi
1Servicio de Dermatología, Hospital de Navarra, Pamplona, España. amaialarumbe@hotmail.com
Abstract:
Cowden disease is a rare genetic disorder characterized by the presence of multiple hamartomas in the skin, thyroid, breast, nervous system and gastrointestinal tract. Mucocutaneous lesions are the most constant and characteristic finding. Breast and thyroid neoplasms (benign and malignant) develop in up to two thirds of patients. Inverted follicular keratosis as the presenting feature of Cowden disease is rare as the disease is usually suspected by the appearance of multiple facial trichilemmomas, oral mucosal papillomatosis and acral keratoses.
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