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Updated: Jul 13, 2026
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A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
Published on: January 5, 2017
[Annexin A2 expression in head and neck squamous cell carcinoma]
Juan Pablo Rodrigo Tapia1, Emma Pena Alonso, Juana M García-Pedrero
1Instituto Universitario de Oncología del Principado de Asturias (IUOPA), Oviedo (Asturias), España. juanpablo.rodrigo@sespa.princast.es
Acta Otorrinolaringologica Espanola
|August 1, 2007
Summary
Annexin A2 (ANXA2) is expressed in head and neck squamous cell carcinomas (HNSCC). Lower ANXA2 expression correlates with poorer tumor differentiation and advanced disease in HNSCC patients.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Context:
- Annexin A2 (ANXA2) over-expression is implicated in various cancers.
- Limited data exists on ANXA2 expression in head and neck squamous cell carcinomas (HNSCC).
Purpose:
- To investigate the expression patterns of ANXA2 in HNSCC.
- To determine the correlation between ANXA2 expression and clinicopathological features of HNSCC.
Summary:
- ANXA2 expression was analyzed via immunohistochemistry in premalignant lesions and HNSCC tissues.
- Reduced ANXA2 expression was noted in dysplastic tissues compared to normal.
- ANXA2 was expressed in most HNSCC tumors, with lower expression linked to poor differentiation, larger tumor size, and lymph node metastasis.
Impact:
- Establishes ANXA2 expression in HNSCC for the first time.
- Suggests ANXA2's potential role as a biomarker for HNSCC differentiation status.
- Provides a foundation for further research into ANXA2's function in HNSCC pathogenesis.
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