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Updated: Jul 13, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Assessing research risks systematically: the net risks test.

D Wendler¹, F G Miller

¹Department of Clinical Bioethics, The NIH Clinical Center, National Institutes of Health, Bethesda, MD, USA. dwendler@nih.gov

Journal of Medical Ethics

|August 1, 2007

Summary

Research ethics committees (RECs) face challenges distinguishing therapeutic from non-therapeutic interventions. The net risks test offers a clearer approach by comparing intervention risks and benefits to alternatives, enhancing participant protection.

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Last Updated: Jul 13, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale

Published on: August 25, 2014

Area of Science:

Medical Ethics
Clinical Research Oversight

Background:

Research ethics committees (RECs) utilize dual-track assessment, which complicates risk evaluation due to the ambiguous distinction between therapeutic and non-therapeutic interventions.
This ambiguity poses challenges for RECs in accurately assessing the ethical implications of research protocols.

Purpose of the Study:

To propose and evaluate the net risks test as a more effective method for research ethics committees.
To enhance the protection of human research participants by refining risk assessment methodologies.

Main Methods:

The study contrasts the dual-track assessment with the proposed net risks test.
The net risks test is described as a clinically familiar method focusing on risk-benefit analysis against alternatives.

Main Results:

The net risks test provides a clearer framework for assessing research intervention risks compared to dual-track assessment.
This method shifts focus towards the core ethical obligation of protecting research participants.

Conclusions:

The net risks test offers a superior alternative to dual-track assessment for research ethics committees.
Implementing the net risks test can improve the ethical oversight of clinical research and strengthen participant safety.