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The effects of medications on bone
Stuart B Goodman1, William Jiranek, Edward Petrow
1Department of Orthopaedic Surgery, Stanford University, Stanford, CA 94305-5326, USA.
The Journal of the American Academy of Orthopaedic Surgeons
|August 1, 2007
Summary
Many medications impact bone metabolism, with some intended therapeutic effects like osteoporosis treatment and others causing adverse effects such as rickets. Understanding these drug interactions is crucial for bone health management.
Area of Science:
- Pharmacology
- Bone Metabolism
- Drug Safety
Background:
- Numerous medications used for arthritis, psychiatric, and epileptic disorders can significantly influence bone metabolism.
- These drug effects on bone can be either intended (e.g., osteoporosis treatment) or unintended adverse effects (e.g., drug-induced rickets).
Purpose of the Study:
- To review the profound effects of various medications on bone metabolism.
- To differentiate between intended therapeutic bone effects and adverse drug reactions impacting bone health.
Main Methods:
- Literature review of medications affecting bone metabolism.
- Analysis of drug classes including NSAIDs, DMARDs, bisphosphonates, corticosteroids, and antineoplastics.
Main Results:
- Nonsteroidal anti-inflammatory drugs may delay fracture healing but effects are reversible.
- Bisphosphonates are effective in increasing bone mass for osteoporosis and Paget's disease.
- Corticosteroids and chemotherapy agents generally have adverse effects on bone, increasing fracture risk.
Conclusions:
- Medications have a significant impact on bone metabolism, necessitating careful consideration of both benefits and risks.
- Understanding drug-induced bone effects is vital for optimizing patient care and preventing skeletal complications.
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