Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antifungal hydrogels.

Andreas Zumbuehl1, Lino Ferreira, Duncan Kuhn

  • 1Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, and University Hospitals of Cleveland, OH, USA.

Proceedings of the National Academy of Sciences of the United States of America
|August 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sensory-selective Sciatic Nerve Block with 2',6' Pipecolylxylidine in an Ovine Model.

Anesthesiology·2026
Same author

Dual ligand cooperation at the plasma membrane drives transport of engineered small extracellular vesicles across brain endothelial cells.

Journal of controlled release : official journal of the Controlled Release Society·2026
Same author

Sensory-selective Peripheral and Neuraxial Nerve Blockade with 2',6'-Pipecoloxylidide: Erratum.

Anesthesiology·2026
Same author

Polymeric rapamycin nanoparticles encapsulating ponatinib cause regression of venous malformations in mice.

Science translational medicine·2026
Same author

Polyketal-conjugated tafluprost microparticles enable long-acting glaucoma therapy.

Nature communications·2026
Same author

Precise Spatiotemporal Control of Sensory Nerve Blockade via Light-Triggered Click-Release Uncaging of 2',6'-Pipecoloxylidide.

Angewandte Chemie (International ed. in English)·2026
Same journal

In This Issue.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Long-term cultural continuity across the Neanderthal-modern human sequence at Üçağızlı II Cave, northern Levant.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Dolphins use names to remember whom to avoid.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Retraction for Shaked and Frenkel, Curiouser and curiouser: Meningeal lymphoid structures in the aging brain.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Small but mighty: The outsized role of small water bodies in the global carbon cycle.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Functional traits produce conditional outcomes in different community contexts.

Proceedings of the National Academy of Sciences of the United States of America·2026
See all related articles

A new dextran-based hydrogel, amphogel, effectively kills fungi on contact and prevents infections. This reusable, biocompatible material shows promise for medical devices and industrial surfaces.

Area of Science:

  • Mycology
  • Biomaterials Science
  • Infectious Diseases

Background:

  • Fungal bloodstream infections are a growing concern, particularly with indwelling medical devices.
  • Antifungal materials are needed to prevent device-associated fungal infections.
  • Candida albicans is a common cause of fungal infections.

Purpose of the Study:

  • To develop and evaluate a novel antifungal hydrogel, amphogel, for preventing fungal infections.
  • To assess the efficacy, reusability, and biocompatibility of amphogel.
  • To investigate amphogel's potential in preventing fungal biofilm formation and in vivo infections.

Main Methods:

  • Amphogel was created by adsorbing amphotericin B onto a dextran-based hydrogel.
  • Antifungal activity was tested against Candida albicans, assessing contact time and reusability.

Related Experiment Videos

  • Biocompatibility was evaluated through in vivo implantation in mice and in vitro hemolysis assays.
  • Fungal infection prevention and biofilm mitigation were assessed in mouse models.

    • Main Results:

    • Amphogel demonstrated rapid antifungal activity, killing fungi within 2 hours of contact.
    • The material maintained effectiveness against Candida albicans after at least 53 reuse cycles.
    • Amphogel proved biocompatible in vivo and did not cause hemolysis in human blood.
    • Implantation of amphogel in mice prevented fungal infection and mitigated biofilm formation.

    Conclusions:

    • Amphogel is a highly effective, reusable, and biocompatible antifungal hydrogel.
    • This material offers a promising strategy for preventing fungal infections associated with medical devices.
    • Amphogel has potential applications in coating medical devices and industrial surfaces to combat fungal contamination.