Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Perioperative outcomes of neoadjuvant immunochemoradiotherapy versus immunochemotherapy followed by surgery in elderly patients with locally advanced esophageal squamous cell carcinoma.

Surgery·2026
Same author

Correction: Call for Decision Support for Electrocardiographic Alarm Administration Among Neonatal Intensive Care Unit Staff: Multicenter, Cross-Sectional Survey.

Journal of medical Internet research·2026
Same author

Integrated physiological, transcriptomic and metabolomic analyses shed light on the complex mechanisms underlying low temperature resistance in kiwifruit (Actinidia arguta).

Plant physiology and biochemistry : PPB·2026
Same author

Effect of a Quality Management System on Preventing Peripherally Inserted Central Catheter-Related Complications Among Pediatric Patients With Hematology Disorders.

Cancer nursing·2026
Same author

ASO Visual Abstract: Impact of Muscle Mass Loss on Survival During Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Esophageal Squamous Cell Carcinoma: A Multi-Center Retrospective Study in China (TIMES Study).

Annals of surgical oncology·2026
Same author

Successful treatment by high dose glucocorticoid of miliary tuberculosis complicated with acute respiratory distress syndrome: a case report.

BMC infectious diseases·2026

Related Experiment Video

Updated: Jul 13, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

Fluoroscopic tracking of multiple implanted fiducial markers using multiple object tracking.

Xiaoli Tang1, Greg C Sharp, Steve B Jiang

  • 1Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

Physics in Medicine and Biology
|August 1, 2007
PubMed
Summary

This study introduces a new multi-marker tracking system for radiotherapy, improving tumor localization accuracy during treatment. The system successfully tracks multiple fiducial markers, even with breathing motion, significantly reducing tracking errors.

More Related Videos

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
07:13

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation
10:25

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation

Published on: September 2, 2025

Related Experiment Videos

Last Updated: Jul 13, 2026

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy
07:43

In Vivo Quantification of Hip Arthrokinematics during Dynamic Weight-bearing Activities using Dual Fluoroscopy

Published on: July 2, 2021

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities
07:13

Multimodal Cross-Device and Marker-Free Co-Registration of Preclinical Imaging Modalities

Published on: October 27, 2023

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation
10:25

Technical Approach for Infrared Tracking for Soft Tissue Navigation with a Holographic Head-Mounted Display and Preclinical Validation

Published on: September 2, 2025

Area of Science:

  • Medical Physics
  • Radiotherapy Technology
  • Image-Guided Interventions

Background:

  • Precise tumor localization is crucial for mobile tumor treatment using radiotherapy techniques like beam gating or tracking.
  • Fluoroscopic tracking of implanted fiducial markers is a common method for tumor position localization.
  • Multiple markers are often preferred over single markers for enhanced accuracy in radiotherapy.

Purpose of the Study:

  • To develop and evaluate a novel marker tracking system capable of simultaneously tracking multiple fiducial markers.
  • To assess the system's robustness in maintaining tracking accuracy, even when markers are obscured by bony anatomy.
  • To investigate the system's ability to detect tracking failures and its performance with and without incorporating breathing pattern information.

Main Methods:

  • Utilized the integrated radiotherapy imaging system (IRIS) for fluoroscopy video acquisition.
  • Developed a tracking system integrating marker detection with a multiple object tracking process inspired by multiple hypothesis marker tracking (MHT).
  • Incorporated breathing pattern information to enhance tracking and retrospectively analyzed data from two liver cancer patients.

Main Results:

  • The proposed system successfully tracked multiple markers simultaneously and robustly, outperforming conventional single-object tracking methods.
  • The system demonstrated effective detection of tracking failures, a critical safety feature for clinical radiotherapy.
  • Incorporating breathing pattern information reduced the failure rate to 0% 75% of the time, with a low maximum marker tracking error (e(95)) of <1.5 mm.

Conclusions:

  • The developed multi-marker tracking system significantly improves the accuracy and reliability of tumor localization in radiotherapy.
  • The system's ability to track markers through bony anatomy and detect failures enhances patient safety.
  • Utilizing breathing pattern information further optimizes tracking performance, leading to near-zero failure rates and minimal positional errors.