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Terahertz Imaging and Characterization Protocol for Freshly Excised Breast Cancer Tumors
Published on: April 5, 2020
A method for analyzing electrical impedance spectroscopy data from breast cancer patients
Bong Seok Kim1, David Isaacson, Hongjun Xia
1Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY 12180, USA.
Physiological Measurement
|August 1, 2007
Summary
Electrical impedance imaging shows promise for breast cancer detection. By analyzing conductivity and permittivity differences between cancerous and normal breast tissues, this method could improve diagnostic accuracy.
Area of Science:
- Biomedical Engineering
- Medical Imaging
- Electrical Engineering
Background:
- Breast tumors exhibit distinct electrical properties (conductivity, permittivity) compared to normal tissues.
- Electrical impedance imaging offers a potential non-invasive method for breast cancer detection.
Purpose of the Study:
- To describe a method for collecting electrical impedance spectroscopy (EIS) data concurrently with tomosynthesis imaging.
- To analyze EIS data for electrode contact verification and to assess its utility in differentiating malignant from benign breast lesions.
Main Methods:
- Simultaneous acquisition of EIS and tomosynthesis data from patients.
- Application of canonical voltage patterns and synthesis of constant voltage data.
- Generation and analysis of Cole-Cole plots from measured currents across multiple frequencies (5-300 kHz).
Main Results:
- Demonstrated a procedure for integrating EIS and tomosynthesis data acquisition.
- Illustrated the potential of Cole-Cole plots to distinguish between cancerous and benign breast lesions based on electrical impedance spectra.
Conclusions:
- Electrical impedance spectroscopy, when combined with tomosynthesis, shows potential for improved breast cancer diagnosis.
- Cole-Cole plots derived from EIS data may serve as a valuable tool in differentiating breast lesions.
