Related Experiment Video

Updated: Jul 13, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Urticaria pigmentosa

Ritambhra1, H Mohan, A Tahlan

  • 1Department of Pathology, Government Medical College, Chandigarh, India.

Indian Journal of Dermatology, Venereology and Leprology
|August 1, 2007
PubMed

Insights

A pediatric case study describes a 2-year-old child with skin papules and blisters. Histopathology confirmed perivascular mast cell infiltration, responding well to symptomatic treatment.

Area of Science:

  • Pediatric Dermatology
  • Histopathology
  • Mast Cell Biology

Background:

  • A 2-year-old child presented with a year-long history of multiple brownish papules on the trunk and limbs.
  • The child also experienced occasional blister formation, suggesting an underlying dermatological condition.

Purpose of the Study:

  • To describe a pediatric case with specific dermatological manifestations.
  • To investigate the histopathological findings associated with the presented symptoms.
  • To evaluate the efficacy of symptomatic treatment for this condition.

Main Methods:

  • Clinical observation and documentation of a pediatric patient's symptoms.
  • Histopathological examination of skin biopsy to identify cellular infiltration.
  • Assessment of treatment response to topical corticosteroids and oral antihistamines.

Main Results:

  • Histopathology revealed significant perivascular mast cell infiltration.
  • The patient's symptoms, including papules and blisters, showed improvement.
  • Symptomatic treatment with topical corticosteroids and oral antihistamines proved effective.

Conclusions:

  • Perivascular mast cell infiltration is a key histopathological finding in this pediatric case.
  • Symptomatic management including topical corticosteroids and oral antihistamines can effectively treat such conditions.
  • This case highlights the importance of histopathology in diagnosing and managing pediatric dermatological disorders involving mast cells.

More Related Videos

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Related Concept Videos

Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Epistasis01:39

Epistasis

In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...