Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within the One...
Mechanism of Antibiotic Resistance in MRSA01:25

Mechanism of Antibiotic Resistance in MRSA

Antibiotic resistance in bacteria arises when microorganisms evolve the ability to withstand drugs designed to kill them or inhibit their growth, rendering once-effective treatments useless. This phenomenon, driven by genetic change and selection under antibiotic exposure, poses a profound threat to modern medicine. Mechanisms include drug-inactivating enzymes (e.g., β-lactamases), efflux pumps that eject antibiotics, mutations altering antibiotic targets, decreased drug uptake, and acquisition...
Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Post-hospitalized Health Conditions of Covid-19 patients: A Cross-sectional study in Bangladesh.

Mymensingh medical journal : MMJ·2026
Same author

Cross-sectional survey of the incidence, mortality and socioeconomic burden of snakebite envenoming in India.

Nature communications·2025
Same author

Observation of τ Lepton Pair Production in Ultraperipheral Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2023
Same author

Search for Exotic Higgs Boson Decays H→AA→4γ with Events Containing Two Merged Diphotons in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2023
Same author

Observation of Same-Sign WW Production from Double Parton Scattering in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2023
Same author

Measurements of jet multiplicity and jet transverse momentum in multijet events in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023

Related Experiment Video

Updated: Jul 13, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Antimicrobial susceptibility pattern among methicillin resistant Staphylococcus isolates in Assam.

D Majumder1, J S Bordoloi, A C Phukan

  • 1Mahanta, India.

Indian Journal of Medical Microbiology
|August 1, 2007
PubMed
Summary

Methicillin-resistant Staphylococcus aureus (MRSA) is prevalent in Assam, with over 50% of S. aureus isolates showing resistance. MRSA strains exhibit significantly higher multidrug resistance compared to sensitive strains.

Related Experiment Videos

Last Updated: Jul 13, 2026

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria
14:04

Biosensor for Detection of Antibiotic Resistant Staphylococcus Bacteria

Published on: May 8, 2013

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Antimicrobial Resistance

Background:

  • Staphylococcus aureus is a common cause of hospital-acquired infections.
  • Methicillin resistance in Staphylococcus aureus (MRSA) poses a significant public health challenge globally.
  • Understanding local prevalence and resistance patterns is crucial for effective treatment strategies.

Purpose of the Study:

  • To determine the prevalence of methicillin-resistant Staphylococcus aureus (MRSA) and coagulase-negative staphylococci (CoNS) in a referral hospital in Assam.
  • To assess antibiotic resistance patterns, particularly multidrug resistance, in MRSA and methicillin-sensitive Staphylococcus aureus (MSSA) isolates.
  • To compare ciprofloxacin resistance in Assam with national data.

Main Methods:

  • Microbiological analysis of Staphylococcus aureus and coagulase-negative staphylococci isolates.
  • Phenotypic detection of methicillin resistance.
  • Antibiotic susceptibility testing for various antibiotics, including ciprofloxacin.
  • Statistical analysis to compare resistance patterns between MRSA and MSSA.

Main Results:

  • A high prevalence of methicillin resistance was observed: 52.9% in Staphylococcus aureus and 15% in coagulase-negative staphylococci.
  • Methicillin-resistant strains showed significantly higher resistance to multiple antibiotics (23.2%) compared to methicillin-sensitive strains (6.6%).
  • Ciprofloxacin resistance rates were lower than those reported in other regions of India.

Conclusions:

  • Methicillin-resistant Staphylococcus aureus is a significant issue in this Assam referral hospital, necessitating enhanced infection control measures.
  • The higher multidrug resistance in MRSA strains underscores the need for judicious antibiotic use and development of targeted therapies.
  • Lower ciprofloxacin resistance may indicate regional variations, warranting further investigation and surveillance.