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EMM types of Streptococcus pyogenes in Chennai

T Menon1, A M Whatmore, S Srivani

  • 1Department of Microbiology, Dr ALM PGIBMS, University of Madras, Chennai, India.

Indian Journal of Medical Microbiology
|August 1, 2007
PubMed

Insights

Group A Streptococcus (GAS) M protein typing is shifting to emm gene sequencing. This study identifies prevalent emm types in South India, finding a diverse distribution among clinical isolates.

Area of Science:

  • Microbiology
  • Molecular Epidemiology
  • Infectious Diseases

Background:

  • The M protein of Group A Streptococcus (GAS) is a key virulence factor.
  • Traditional serologic M typing is being superseded by molecular methods like emm gene sequencing.
  • Understanding the distribution of emm types is crucial for epidemiology and vaccine development.

Purpose of the Study:

  • To report the prevalent emm types of Group A Streptococcus (GAS) in South India for the first time.
  • To characterize the molecular epidemiology of GAS in this region.
  • To provide baseline data for future public health interventions.

Main Methods:

  • Clinical isolates of GAS were collected.
  • emm gene sequencing was performed to determine M types.
  • Sequence data was analyzed to identify prevalent types and their distribution.

Main Results:

  • A diverse range of emm types were identified among the clinical isolates.
  • No single emm sequence showed a marked preponderance.
  • Eleven different emm sequences were found in 34 analyzed isolates.

Conclusions:

  • emm gene sequencing is a viable alternative for M typing in South India.
  • GAS isolates in South India exhibit a varied emm type distribution.
  • Further surveillance is needed to monitor GAS epidemiology in the region.

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