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Status of uric acid management in hypertensive subjects

Yasutaka Yamamoto1, Koichi Matsubara, Go Igawa

  • 1Division of Regenerative Medicine and Therapeutics, Tottori University Graduate School of Medical Sciences, Yonago, Japan. yasutaka@grape.med.tottori-u.ac.jp

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|August 1, 2007
PubMed

Insights

Hyperuricemia is common in hypertensive patients, particularly men. While doctors monitor uric acid, intensive management and treatment are lacking, increasing cardiovascular disease risk.

Area of Science:

  • Cardiology
  • Nephrology
  • Endocrinology

Background:

  • Hyperuricemia is a known risk factor for cardiovascular diseases (CVDs) in hypertensive individuals.
  • Effective management of serum uric acid levels is crucial for CVD prevention in this population.

Purpose of the Study:

  • To investigate the current status of uric acid management in hypertensive patients.
  • To identify factors associated with hyperuricemia and assess treatment adherence and target achievement.

Main Methods:

  • A study involving 799 hypertensive patients (mean age 70.9 years) and 43 physicians.
  • Analysis of serum uric acid levels, prevalence of hyperuricemia, and medication use.
  • Comparison of management strategies across different patient demographics and physician specialties.

Main Results:

  • Hyperuricemia prevalence was 17.5%, higher in men and associated with specific comorbidities and lifestyle factors.
  • Serum uric acid levels were elevated in men and patients with heart failure, renal dysfunction, high triglycerides, low HDL, smokers, and those on beta-blockers.
  • Only 50% of hyperuricemic patients received medication, with less than half achieving the target level (6 mg/dL).

Conclusions:

  • Despite high physician awareness, uric acid management in hypertensive patients is suboptimal.
  • Intensive intervention and tailored treatment strategies are needed to improve outcomes and reduce CVD risk.
  • Enhanced attention to uric acid monitoring and management is essential for hypertensive individuals.

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