Related Experiment Video
Updated: Jul 13, 2026

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Prognostic value of left atrial volume index in hemodialysis patients
Silvio H Barberato1, Roberto Pecoits Filho
1Pontifícia Universidade Católica do Paraná, Curitiba, PR, Brasil. silviohb@cardiol.br
Insights
Left atrial volume index (LAVi) independently predicts prognosis in hemodialysis patients. This measure offers valuable insights beyond traditional clinical and echocardiographic data for assessing cardiovascular risk.
Area of Science:
- Cardiology
- Nephrology
- Medical Imaging
Background:
- Cardiovascular disease is a leading cause of mortality in hemodialysis patients.
- Traditional risk factors and echocardiographic parameters have limitations in predicting outcomes.
Purpose of the Study:
- To assess the prognostic significance of left atrial volume index (LAVi) in hemodialysis patients.
- To compare the predictive value of LAVi against established clinical and echocardiographic markers.
Main Methods:
- Echocardiograms were performed on 118 hemodialysis patients.
- Patients were followed for a composite endpoint of mortality and cardiovascular events.
- Cox multivariate analysis was employed to determine independent predictors.
Main Results:
- LAVi was identified as an independent predictor of prognosis in hemodialysis patients.
- LAVi provided incremental prognostic information beyond left ventricular mass, ejection fraction, and clinical variables.
- The association remained significant after adjusting for traditional risk factors.
Conclusions:
- Left atrial volume index is a valuable independent prognostic marker in hemodialysis patients.
- LAVi enhances risk stratification by adding information to conventional clinical and echocardiographic assessments.
Objective:
To evaluate the prognostic value of left atrial volume index (LAVi) in the clinical course of hemodialysis (HD) patients, compared with previously established echocardiographic and clinical parameters.
Methods:
Echocardiograms were obtained from 118 hemodialysis patients, who were then followed for 19 +/- 8 months. Study endpoint was a composite of all-cause mortality and nonfatal cardiovascular events. Cox multivariate analysis was used do assess the independent prognostic value of LAVi.
Results:
On univariate analysis, LAVi and other clinical and echocardiographic parameters were predictive of prognosis. Multivariate analyses showed that LAVi was an independent predictor of prognosis (hazard ratio 1.03 per ml/m(2), 95% confidence interval: 1.01 to 1.05, p=0.014), and added incremental information to the model containing traditional predictors of cardiovascular risk, such as left ventricular mass, ejection fraction, and clinical variables (p=0.02).
Conclusion:
LAVi is an independent predictor of prognosis in HD patients, providing incremental information to traditional clinical and Doppler echocardiographic data.
Related Concept Videos
Hemodialysis I: Introduction
Hemodialysis II: Procedure and Complications
Hemodialysis III: Nursing Management
Acute Kidney Injury IV: Diagnostic Studies and Prevention
