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Early destructive lesions in the developing brain: clinical and electrographic correlates
Cristiane Low1, Eliana Garzon, Henrique Carrete
1UNIPETE - Unidade de Pesquisa e Tratamento das Epilepsias - Departamento de Neurologia e Neurocirurgia, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP, Brasil.
Arquivos De Neuro-Psiquiatria
|August 1, 2007
Summary
Destructive brain lesions like porencephaly (POR) and multicystic encephalopathy (MCE) showed no direct link to clinical outcomes. However, increased epileptiform discharge frequency correlated with brain atrophy, and MCE was linked to gliosis.
Area of Science:
- Neurology
- Neuroscience
- Pediatric Neurology
Background:
- Early brain insults can lead to cavitary lesions such as porencephaly (POR) and multicystic encephalopathy (MCE).
- These destructive brain lesions can have significant long-term clinical and electrographic consequences.
Purpose of the Study:
- To investigate the clinical and electrographic correlates of destructive brain lesions, specifically porencephaly (POR) and multicystic encephalopathy (MCE).
- To identify potential associations between lesion type, clinical presentation, and electrophysiological findings.
Main Methods:
- A cohort of patients with POR and MCE underwent clinical evaluation and Video-EEG monitoring.
- Analysis included demographic data, lesion type, gliosis, perinatal complications, epilepsy history, brain atrophy, and epileptiform discharge characteristics.
Main Results:
- Fourteen patients had MCE and six had POR; 18 presented with hemiparesis and 19 with epilepsy.
- Sixteen patients exhibited epileptiform discharges, with seven experiencing refractory seizures.
- All MCE patients showed gliosis, contrasting with only two POR patients.
Conclusions:
- No correlation was found between lesion type (POR vs. MCE) and clinical or electrographic outcomes.
- A positive correlation was observed between the frequency of epileptiform discharges and the presence of brain atrophy.
- Multicystic encephalopathy (MCE) was positively correlated with gliosis.
