[Cardiovascular alterations and sudden death in epilepsy]

Area of Science:

• Neurology
• Cardiology

Context:

• Epilepsy is a prevalent neurological disorder.
• Sudden unexpected death in epilepsy (SUDEP) is the primary direct cause of epilepsy-related mortality.
• The exact mechanisms underlying SUDEP remain largely unknown.

Purpose:

• To review and emphasize the relationship between SUDEP and cardiac abnormalities.
• To explore potential cardiac mechanisms contributing to SUDEP.

Summary:

• This review highlights the association between cardiac abnormalities and SUDEP.
• Cardiac dysfunction is a frequently proposed mechanism for SUDEP.
• Further research into cardiac factors is crucial for understanding and potentially preventing SUDEP.

Impact:

• This review can guide future research into the etiology of SUDEP.
• Understanding the cardiac role in SUDEP may lead to improved patient monitoring and risk stratification.
• Findings could inform clinical practice and potentially reduce SUDEP incidence.