Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

131 I-induced changes in rat thyroid gland function.

V Torlak1, T Zemunik, D Modun

  • 1Department of Nuclear Medicine, Clinical Hospital Split, University of Split, Soltanska 2, 21000 Split, Croatia.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|August 1, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Psychometric properties and observational data for COVID-19 Yorkshire Rehabilitation Scale (C19-YRSm) for post-COVID-19 syndrome.

QJM : monthly journal of the Association of Physicians·2023
Same author

Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone.

Journal of endocrinological investigation·2019
Same author

Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial.

The British journal of dermatology·2019
Same author

Obstructive sleep apnea in children: How it affects parental psychological status?

International journal of pediatric otorhinolaryngology·2018
Same author

Genome-wide association analysis suggests novel loci for Hashimoto's thyroiditis.

Journal of endocrinological investigation·2018
Same author

[Anaplastic Thyroid Carcinoma in a 17-Year-Old Female Patient].

Acta medica Croatica : casopis Hravatske akademije medicinskih znanosti·2017
Same journal

RETRACTION: NOP14 inhibits melanoma proliferation and metastasis by regulating Wnt/β-catenin signaling pathway.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Differential expression of microRNA-411 and 376c is associated with hypertension in pregnancy.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

RETRACTION: Comparison of two treatments for dry eye disease after corneal refractive surgery.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

The emerging role of the microbiome in bladder cancer: prognostic implications and treatment response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

Standardizing the lateral fluid percussion model of trauma in marmosets (Callithrix jacchus): regional vulnerability and inflammatory response.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
Same journal

COVID-19 mortality risk among women with ovarian cancer: a matched case-control study.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·2026
See all related articles

Radioactive iodine ((131)I) treatment can lead to thyroid failure. This study in rats showed that (131)I caused prolonged hypothyroidism, regardless of the dose administered.

Area of Science:

  • Endocrinology
  • Nuclear Medicine
  • Toxicology

Background:

  • Therapeutic doses of radioactive iodine ((131)I) are used for hyperthyroidism but can induce hypothyroidism.
  • The dose-dependent effects of (131)I on thyroid function require further investigation in preclinical models.

Purpose of the Study:

  • To evaluate the long-term effects of different doses of (131)I on thyroid function and gland morphology in a rat model.
  • To determine if the observed thyroid dysfunction is dependent on the administered (131)I dose.

Main Methods:

  • Male Fisher rats received varying doses of (131)I (64-277 microCi) or served as controls.
  • Hormone levels (thyroxine, triiodothyronine, TSH) were measured at baseline and over 6 months post-administration.
  • Thyroid gland weight, volume, and histopathology were assessed at study termination.

Related Experiment Videos

Main Results:

  • Rats treated with (131)I exhibited significant alterations in serum triiodothyronine and TSH levels compared to controls.
  • Thyroxine levels decreased significantly in the (131)I-treated group over time.
  • Histopathological analysis revealed thyroid gland damage, including vascular changes, follicular necrosis, and inflammation, irrespective of the (131)I dose.

Conclusions:

  • Administration of (131)I to rats results in prolonged hypothyroidism.
  • Histopathological changes and hormonal imbalances indicate significant thyroid damage after (131)I exposure.
  • The observed hypothyroidism and thyroid pathology were not dependent on the dose of (131)I administered in this rat model.