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Directed Assembly of Elastin-like Proteins into defined Supramolecular Structures and Cargo Encapsulation In Vitro
Published on: April 8, 2020
Self-assemblies of amphiphilic cyclodextrins
Michel Roux1, Bruno Perly, Florence Djedaïni-Pilard
1CEA/DSV/iBiTecS - URA CNRS 2096, Laboratoire Protéines Membranaires, Gif sur Yvette, 91191, France, michel.roux@cea.fr.
European Biophysics Journal : EBJ
|August 1, 2007
Summary
Amphiphilic cyclodextrins, used as molecular cages, can self-assemble into micelles or integrate into cell membranes. This study details their self-organization, particularly monosubstituted derivatives, for improved drug delivery and targeting.
Area of Science:
- Carbohydrate Chemistry
- Supramolecular Chemistry
- Materials Science
Background:
- Cyclodextrins (CDs) are cyclic oligosaccharides widely utilized as molecular cages in various industries.
- Optimization of CD properties has led to the development of synthetic analogues.
- Amphiphilic CDs are designed for enhanced cell targeting and drug delivery via self-assembly.
Purpose of the Study:
- To review polysubstituted amphiphilic cyclodextrins.
- To detail monosubstituted derivatives of native and methylated beta-cyclodextrins.
- To emphasize the self-organization of these derivatives within lipid membranes.
Main Methods:
- Synthesis of amphiphilic cyclodextrin derivatives.
- Characterization of self-assembly into micelles and aggregates.
- Investigation of insertion and organization within lipid membranes and liposomes.
Main Results:
- Amphiphilic CDs self-assemble into water-soluble aggregates like micelles.
- These derivatives can integrate into biological lipid membranes.
- Monosubstituted derivatives show specific self-organization behaviors within membranes.
Conclusions:
- Amphiphilic cyclodextrins offer versatile self-assembly properties for drug delivery systems.
- Their interaction with lipid membranes is crucial for targeted delivery.
- Further research into these derivatives can advance pharmaceutical and biomedical applications.
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