Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Factor D of complement: Uremic toxin?].

M Pascual

    Nephrologie
    |January 1, 1991
    PubMed
    Summary
    This summary is machine-generated.

    Factor D enzyme levels significantly increase in kidney failure, potentially overactivating the complement system. This may contribute to adverse effects in hemodialysis and worsening kidney damage.

    Related Experiment Videos

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical, imaging and rhinoscopy findings of dogs and cats with nasal foreign bodies presenting to a UK referral hospital: 71 cases (2010-2022).

    The Journal of small animal practice·2024
    Same author

    Unravelling the mechanisms underlying the social interaction effects on the feed efficiency of rabbits.

    Animal : an international journal of animal bioscience·2024
    Same author

    Novel phenotypes of feeding and social behaviour and their relationship with individual rabbit growth and feed efficiency.

    Animal : an international journal of animal bioscience·2024
    Same author

    Genomic architecture of carcass and pork traits and their association with immune capacity.

    Animal : an international journal of animal bioscience·2023
    Same author

    Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019).

    The Journal of small animal practice·2023
    Same author

    Short-term outcomes of chemoradiotherapy and local excision versus total mesorectal excision in T2-T3ab,N0,M0 rectal cancer: a multicentre randomised, controlled, phase III trial (the TAU-TEM study).

    Annals of oncology : official journal of the European Society for Medical Oncology·2022
    Same journal

    Short-term effect of folic acid supplementation in renal transplant recipients and chronic kidney disease patients with comparable renal function impairment.

    Nephrologie·2004
    Same journal

    [Acute renal failure and 2,8-dihydroxyadeninuria].

    Nephrologie·2004
    Same journal

    [Phototherapy and hemodialysis pruritus].

    Nephrologie·2004
    Same journal

    [Pregnancy and hemodialysis].

    Nephrologie·2004
    Same journal

    [Role of dietary fibers in the nutritional management of chronic renal failure].

    Nephrologie·2004
    Same journal

    [Abstracts of the VI Meeting of the Society of Nephrology and of the Francophone Society of Dialysis. Marseille, France, 28 September-1 October 2004].

    Nephrologie·2004
    See all related articles

    Area of Science:

    • Immunology
    • Nephrology

    Background:

    • Factor D is a key enzyme in the alternative complement pathway.
    • Renal function is the primary route for Factor D catabolism.

    Discussion:

    • Factor D concentration elevates significantly (approx. 10-fold) in end-stage renal disease.
    • Elevated Factor D leads to enhanced alternative pathway activation.

    Key Insights:

    • Accumulated Factor D in renal failure drives complement system overactivation.
    • The pathophysiological role of excess Factor D requires further investigation.

    Outlook:

    • Investigate the role of Factor D in hemodialysis complications.
    • Determine the contribution of Factor D to progressive renal injury.