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An Optimized Hemagglutination Inhibition (HI) Assay to Quantify Influenza-specific Antibody Titers
Published on: December 1, 2017
[Target groups for influenza vaccination]
Satoko Ohfuji1, Megumi Fujieda, Wakaba Fukushima
1Department of Public Health, Osaka City University Graduate School of Medicine.
Insights
The US Advisory Committee on Immunization Practices (ACIP) expanded influenza vaccination target groups over a decade. Key changes include vaccinating all young children and individuals in close contact with infants.
Area of Science:
- Public Health
- Immunology
- Epidemiology
Context:
- Influenza vaccination is crucial for preventing seasonal outbreaks and associated complications.
- Recommendations for influenza vaccination target groups evolve based on epidemiological data and risk assessment.
- The US Advisory Committee on Immunization Practices (ACIP) provides guidelines for influenza vaccination strategies.
Purpose:
- To analyze and compare the target groups for influenza vaccination as defined by the US Advisory Committee on Immunization Practices (ACIP) between 1997 and 2006.
- To identify significant shifts in vaccination policy over a ten-year period.
Summary:
- The ACIP progressively broadened the scope of recommended influenza vaccination recipients.
- Major updates include the inclusion of all children aged 6-59 months and pregnant women throughout their pregnancy.
- New high-risk categories encompass individuals with neuromuscular disorders and those at increased risk of healthcare visits due to influenza, alongside expanded definitions for transmission risk groups.
Impact:
- These policy shifts aim to enhance population immunity and reduce the burden of influenza-related morbidity and mortality.
- The expanded recommendations reflect a proactive approach to influenza prevention, particularly for vulnerable populations.
- Understanding these changes is vital for healthcare providers and public health officials in implementing effective vaccination programs.
Purpose:
To assess target groups for influenza vaccination.
Methods:
The target groups for influenza vaccination specified in the recommendations of the US Advisory Committee on Immunization Practices (ACIP) were summarized and compared between 1997 and 2006.
Results:
Principal changes after the 1997's recommendation are as follows: 1) all children aged 6-59 months became included into the high risk group for active vaccination; 2) recommendation for vaccination timing of pregnant women was extended from those at the second trimester or after to all women who are pregnant during the influenza season; 3) persons with neuro- or muscular-disorders and therefore prone to development of respiratory systems or aspiration pneumonia became included into the high risk group; 4) a category with increased risk to visit a clinic, hospital or emergency department due to influenza-related symptoms was newly established, covering children aged 24-59 months and persons aged 50-64 years; 5) healthy household contacts and caregivers of children aged 0-59 months were included into the group who can transmit influenza to persons in the high risk group; 6) people likely to transmit influenza to persons in the high risk group were classified into 3 categories (health-care providers, household contacts and caregivers, and those in close contact with children aged 0-59 months).
Conclusion:
The ACIP has gradually expanded the target populations for routine influenza vaccination. The most notable change during past 10 years seems to be the recommendation for inclusion of all children aged 6-59 months and people in close contact with babies for active vaccination.
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