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Synthesis and evaluation of ethylnitrosoureas of substituted naphthalimides as anticancer compounds

Anindita Pain1, Suva Samanta, Sushanta Dutta

  • 1Department of Anticancer Drug Development, Chittaranjan National Cancer Institute, Kolkata - 700026, India.

Acta Poloniae Pharmaceutica
|August 2, 2007
PubMed

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Preparation of 1° Amines: Gabriel Synthesis

Direct alkylation is not a suitable method for synthesizing amines because it produces polyalkylated products. Gabriel synthesis is the most preferred method to exclusively make primary amines. The method uses phthalimide, which contains a protected form of nitrogen that participates in alkylation only once to predominantly give primary amines.
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