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Inhibition of IS2 transposition by factor for inversion stimulation

Guang-Sheng Lei1, Chii-Jaan Chen, Hanna S Yuan

  • 1Graduate Institute of Microbiology and Immunology, National Yang-Ming University, Taipei, Taiwan, Republic of China.

FEMS Microbiology Letters
|August 2, 2007
PubMed
Summary

The factor for inversion stimulation (Fis) protein inhibits IS2 transposition in Escherichia coli by binding to key DNA sites. Fis reduces IS2 gene transcription and blocks transposase binding, significantly lowering transposition frequency.

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