Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Blood Transfusion and Agglutination

Blood Transfusion and Agglutination

Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...

Structure and Function of Platelets

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...

Formation of the Platelet Plug

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

Blood Transfusion

Blood Transfusion

Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Pulmonary Embolism II: Diagnostic Studies and Interprofessional Care

Diagnosing Pulmonary EmbolismDiagnosing pulmonary embolism (PE) involves clinical assessment and advanced imaging tests. The preferred diagnostic tool is the spiral (helical) CT scan or CT angiography (CTA), which uses intravenous contrast media to visualize the pulmonary vasculature and identify emboli.A ventilation-perfusion (V/Q) scan is an alternative for patients unable to receive contrast media. This scan includes both perfusion and ventilation scanning. Perfusion scanning involves...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of Ado-Trastuzumab Emtansine on Autologous Platelet Kinetics and Function.

JCO precision oncology·2022

Same author

Fecal blood loss: A quantitative method of evaluating hemostasis in patients with thrombocytopenia.

Transfusion·2020

Same author

The impact of donor sex and age on stored platelet metabolism and post-transfusion recovery.

Blood transfusion = Trasfusione del sangue·2020

Same author

Transfusion-related immunomodulation: gamma irradiation alters the effects of leukoreduction on alloimmunization.

Transfusion·2019

Same author

Pathogen reduction with amotosalen/UVA reduces platelet refractoriness in a dog platelet transfusion model.

Vox sanguinis·2019

Same author

Platelets stored in whole blood at 4°C: in vivo posttransfusion platelet recoveries and survivals and in vitro hemostatic function.

Transfusion·2019

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Routine Screening Method for Microparticles in Platelet Transfusions

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Platelet transfusion therapy.

Sherrill J Slichter¹

¹Puget Sound Blood Center, 921 Terry Avenue, Seattle, WA 98104-1256, USA. sjslichter@psbc.org

Hematology/Oncology Clinics of North America

|August 2, 2007

Summary

This article offers guidelines for appropriate platelet transfusions, aiming to minimize risks and costs associated with unnecessary procedures. It covers platelet products, adverse effects, and strategies for managing poor responses to transfusions.

Area of Science:

Hematology
Transfusion Medicine

Background:

Platelet transfusions are critical for managing bleeding disorders but carry risks.
Unnecessary transfusions increase patient risk and healthcare costs.

Purpose of the Study:

To provide guidelines for appropriate platelet transfusion use.
To reduce unnecessary transfusions and associated risks.
To outline management of adverse transfusion events.

Main Methods:

Review of available platelet products (whole blood-derived, apheresis).
Discussion of strategies to mitigate transfusion reactions (leukoreduction, irradiation).
Analysis of factors influencing transfusion response and refractoriness.

Main Results:

More Related Videos

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Related Experiment Videos

Last Updated: Jul 13, 2026

Routine Screening Method for Microparticles in Platelet Transfusions

Routine Screening Method for Microparticles in Platelet Transfusions

Published on: January 31, 2018

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Treatment of Platelet Products with Riboflavin and UV Light: Effectiveness Against High Titer Bacterial Contamination

Published on: August 24, 2015

Microfluidics in Assessing Platelet Function

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Guidelines for appropriate pretransfusion platelet counts and doses are presented.
Strategies for preventing and managing adverse consequences are detailed.
Factors contributing to poor platelet response (alloimmunization, disease state) are identified.

Conclusions:

Appropriate use of platelet transfusions can minimize risks and costs.
Understanding factors affecting transfusion response is crucial for effective therapy.
Management strategies for platelet refractoriness are essential.