Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Structure and Function of Platelets01:18

Structure and Function of Platelets

The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
Platelets are continually replenished, circulating in the bloodstream for 9-12 days before being removed by phagocytes, primarily in the spleen. A microliter of circulating blood contains between 150,000 and 450,000 platelets, with...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A randomized, double-blind, controlled, parallel group study with amustaline/glutathione pathogen reduced red blood cells in regions at potential risk for Zika virus transfusion-transmitted infections (RedeS Study)-protocol for a phase 3 clinical trial.

Trials·2026
Same author

Hyperhemolysis in a sickle cell disease patient in pregnancy.

Annals of hematology·2025
Same author

How do we manage hyperhemolysis syndrome.

Transfusion·2024
Same author

Evaluation of an automated von Willebrand factor glycoprotein IbM activity assay compared with 3 alternative von Willebrand factor activity assays.

Research and practice in thrombosis and haemostasis·2024
Same author

High annualized bleeding rates in pediatric patients with inherited platelet function disorders.

Haematologica·2024
Same author

Clinical Laboratory Experiences During the COVID-19 Pandemic.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America·2023

Related Experiment Video

Updated: Jul 13, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Laboratory evaluation of platelet function.

Adam Seegmiller1, Ravindra Sarode

  • 1Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, TX 75390-9073, USA.

Hematology/Oncology Clinics of North America
|August 2, 2007
PubMed
Summary

Understanding platelet quantity and function tests is crucial for diagnosing bleeding disorders and monitoring antiplatelet therapy. This review covers essential platelet physiology and common clinical assessment methods.

More Related Videos

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Related Experiment Videos

Last Updated: Jul 13, 2026

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor
06:32

Dynamic Multiparameter Platelet Function Assessment Using a Capacitive Biosensor

Published on: May 2, 2025

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
09:38

A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time

Published on: February 14, 2017

Area of Science:

  • Hematology
  • Hemostasis and Thrombosis

Background:

  • Platelets are critical for hemostasis, impacting bleeding disorders and thrombotic events.
  • Accurate diagnosis and therapy monitoring necessitate understanding platelet quantity and function.

Purpose of the Study:

  • To review basic platelet physiology.
  • To describe common clinical tests for assessing platelet function.

Main Methods:

  • Literature review of platelet physiology.
  • Description of established clinical diagnostic tests for platelet function.

Main Results:

  • Key concepts of platelet physiology are outlined.
  • Commonly used clinical tests for platelet assessment are detailed.

Conclusions:

  • A comprehensive understanding of platelet tests is vital for clinical practice.
  • This review provides foundational knowledge for diagnosing platelet-related disorders and managing antiplatelet treatments.