[Genetic characteristics of six Chinese Han keloid pedigrees]

To study the genetic characteristics of keloid in 6 Chinese Han pedigrees.

The clinical data of 6 unrelated Chinese Han keloid pedigrees were collected, and their pedigree charts were constructed and the inheritance patterns analyzed.

Keloid onset in the patients of these pedigrees mainly occurred during adolescence, with equal chance for involvement in male and female subjects. The affected individual could be heterozygous, and a child with one affected parent had a 50% chance of being affected. The trait of keloid was transmitted consecutively in 3 pedigrees, showing complete penetrance, but in the other 3 pedigrees, it was transmitted intermittently, suggesting incomplete penetrance. The clinical phenotype of keloid presented a variable expression among the affected individuals in these pedigrees.

The inheritance pattern observed in these Chinese Han keloid pedigrees is consistent with an autosomal dominant inheritance with incomplete penetrance, variable expressivity and delayed dominance.