[Integrated therapy and research progress in molecular therapy for intracranial tumor]

Intracranial tumor is the most common primary neoplasm in the central nervous system, it is a complex, heterogeneous and hard to cure disease. Current treatments include gross resection of the tumor, radiotherapy, chemotherapy, immunotherapy and Chinese medicine treatment. Despite valiant efforts, prognosis remains dismal. The thrust of an integrated approach to increase disease-free survival and improve quality-of-life is urgently required. In the era of molecular targeted therapy, recent promising diagnostic and therapeutic strategies have resulted from advancement in understanding molecular brain tumor biology, neuroimaging, neurosurgical treatment, radiotherapy, combined chemotherapy and molecular therapy. This review outlines the current status of diagnosis and therapeutic intervention in intracranial tumor. The article discusses the perspective of molecular therapy. This approach includes new technologies, such as genomics, proteomics, nanomedicine and metabolomics.