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Related Experiment Video

Updated: Jul 13, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Application and Methodology of the Non-destructive ¹⁹F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

Nitrofurantoin neuropathy: a forgotten adverse effect.

Leslie D Kammire¹, Peter D Donofrio

¹Department of Obstetrics and Gynecology, Wake Forest University School of Medicine, Winston-Salem, North Carolina 27157-1066, USA. lkammire@wfubmc.edu

Obstetrics and Gynecology

|August 2, 2007

Summary

Nitrofurantoin, an antibiotic for urinary tract infections, can cause peripheral neuropathy. This rare nerve complication is reversible upon drug discontinuation and often overlooked by physicians.

Related Experiment Videos

Last Updated: Jul 13, 2026

Application and Methodology of the Non-destructive 19F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Application and Methodology of the Non-destructive ¹⁹F Time-domain NMR Technique to Measure the Content in Fluorine-containing Drug Products

Published on: August 22, 2017

Area of Science:

Pharmacology
Neurology
Infectious Diseases

Background:

Nitrofurantoin is a common antibiotic for uncomplicated lower urinary tract infections.
Peripheral neuropathy is an underreported adverse effect in obstetric and gynecologic literature.

Observation:

A patient developed severe sensory neuropathy after 7 years of intermittent and continuous nitrofurantoin use.
Neuropathy symptoms significantly improved after discontinuing the antibiotic.

Findings:

Peripheral neuropathy is a rare, potentially reversible adverse effect of nitrofurantoin.
This complication is frequently unrecognized by prescribing physicians.

Implications:

Increased awareness of nitrofurantoin-induced peripheral neuropathy is crucial for obstetric and gynecologic practitioners.
Early recognition and discontinuation can lead to near-complete recovery from this neurological complication.