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Results of a clinical study of polio vaccine: the Buffalo experience

H Faden1

  • 1Division of Infectious Diseases, State University of New York School of Medicine, Buffalo 14222.

The Pediatric Infectious Disease Journal
|December 1, 1991
PubMed

Insights

This study compared poliovirus vaccine schedules in infants. Combination schedules using inactivated poliovirus vaccine (IPV) and oral poliovirus vaccine (OPV) showed promising antibody responses.

Area of Science:

  • Immunology
  • Vaccinology
  • Pediatrics

Background:

  • Poliovirus remains a global health concern, necessitating effective vaccination strategies.
  • Understanding the immunogenicity of different poliovirus vaccine schedules is crucial for disease eradication efforts.

Purpose of the Study:

  • To evaluate and compare the antibody responses in infants immunized with different schedules of oral poliovirus vaccine (OPV) and inactivated poliovirus vaccine (IPV).

Main Methods:

  • 123 infants received one of four trivalent poliovirus vaccine schedules: OPV-OPV-OPV, IPV-IPV-IPV, IPV-OPV-OPV, or IPV-IPV-OPV.
  • Serum-neutralizing, nasopharyngeal-neutralizing, and nasopharyngeal IgA antibodies were measured.

Main Results:

  • Nearly all infants developed serum-neutralizing antibodies regardless of the vaccine schedule.
  • Combination schedules (IPV-OPV-OPV and IPV-IPV-OPV) elicited the highest antibody titers against specific poliovirus serotypes.
  • Local mucosal immune responses (nasopharyngeal antibodies) were robust across most groups.

Conclusions:

  • Combination IPV and OPV schedules appear to be ideal for inducing comprehensive poliovirus immunity in infants.
  • The feasibility of implementing combination schedules in diverse populations, like the United States, requires further investigation.

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