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Updated: Aug 15, 2026
Pre-clinical Evaluation of Tyrosine Kinase Inhibitors for Treatment of Acute Leukemia
Published on: September 18, 2013
[Results of neuroleukemia prevention in children with acute lymphoblastic leukemia]
Insights
Preventing central nervous system (CNS) involvement in acute lymphoblastic leukemia (ALL) using combined chemo- and radiotherapy significantly reduced neuroleukemia incidence to 5.6%. Most children showed no major neuropsychic changes, though some developed CNS leukemia complications.
Area of Science:
- Pediatric Oncology
- Hematology
- Neurology
Abstract:
The follow-up of 318 children with acute lymphoblastic leukemia given program therapy that included different treatments including chemo- and radioprevention of neuroleukemia demonstrated the high efficacy of the measures carried out, which reduced the incidence of neuroleukemia to 5.6%. No gross changes on the part of the neuropsychic status were revealed in the course of the follow-up of children who received the combined prophylaxis of neuroleukemia. The derangement of the CNS was recorded in 17 patients and ran its course in the form of leukemic meningitis and meningoencephalitis.
