Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Factors Affecting Renal Clearance: Renal Impairment01:17

Factors Affecting Renal Clearance: Renal Impairment

Renal dysfunction significantly impairs the renal clearance of drugs, leading to potential complications in drug therapy. Renal failure, which can be caused by various factors, poses a significant challenge in the elimination of drugs from the body.
One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate01:25

Drug Dosing in Renal Diseases: Measurement of Glomerular Filtration Rate

The glomerular filtration rate (GFR) is a critical indicator of kidney health, reflecting how well the kidneys filter blood. Changes in GFR can signal potential kidney impairment, necessitating accurate measurement methods to monitor kidney function effectively.Various molecules can serve as markers for GFR measurement, with the ideal marker meeting several specific criteria. It must freely filter at the glomerulus, avoid reabsorption or secretion by the renal tubules, remain unmetabolized, not...
Renal Failure: Dose Adjustments01:11

Renal Failure: Dose Adjustments

In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elevations in Donor-Derived Cell-Free DNA and Allograft Outcomes in Kidney Transplantation.

Journal of the American Society of Nephrology : JASN·2026
Same author

Evaluation of nephrolithiasis and its risk factors in living kidney donor candidates.

Current opinion in organ transplantation·2026
Same author

Comparative 3-Year Allograft Outcomes for Recipients of Kidneys From SARS-CoV-2 NAT-Positive Donors.

Transplant infectious disease : an official journal of the Transplantation Society·2026
Same author

Biopsy and Blood Gene Expression Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients.

Transplantation direct·2025
Same author

Outcomes of Deceased Donor Kidney Transplants Allocated Out of Sequence in the United States.

Clinical journal of the American Society of Nephrology : CJASN·2025
Same author

Rethinking Living Donor Kidney Transplantation Through a Healthcare System Lens.

Kidney international reports·2024

Related Experiment Video

Updated: Jul 13, 2026

Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

Evaluation of renal function in transplantation.

Emilio D Poggio1, D Scott Batty, Stuart M Flechner

  • 1Department of Nephrology and Hypertension and Transplant Center, Cleveland Clinic, Cleveland, OH 44195, USA. poggioe@ccf.org

Transplantation
|August 2, 2007
PubMed
Summary

Accurate kidney function assessment is vital post-transplant. Current methods like serum creatinine have limitations, especially for kidney and liver transplant recipients, impacting patient management and outcomes.

More Related Videos

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Related Experiment Videos

Last Updated: Jul 13, 2026

Murine Renal Transplantation Procedure
18:48

Murine Renal Transplantation Procedure

Published on: July 10, 2009

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform
07:13

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Area of Science:

  • Nephrology
  • Transplant Surgery
  • Clinical Chemistry

Background:

  • Kidney dysfunction significantly impacts post-transplant outcomes.
  • Accurate assessment of kidney function is crucial for guiding treatment decisions and preventing renal decline.
  • Limitations exist in current methods for estimating kidney function in transplant patients.

Purpose of the Study:

  • To overview the performance of commonly used kidney function estimation equations and methods.
  • To evaluate these methods in the context of renal and liver transplant recipients.
  • To discuss the potential roles of accurate kidney function assessment in clinical transplantation.

Main Methods:

  • Review of established methods for estimating kidney function, including serum creatinine levels, creatinine-based equations, and creatinine clearance.
  • Analysis of the applicability and limitations of these methods in kidney transplant patients.
  • Examination of kidney dysfunction in nonrenal solid organ transplant recipients, particularly liver transplant patients.

Main Results:

  • Current methods for assessing kidney function, such as serum creatinine and creatinine clearance, demonstrate limitations in the kidney transplant setting.
  • Kidney dysfunction is increasingly recognized as a significant issue in recipients of nonrenal solid organ transplants.
  • The performance of standard estimation equations varies across different transplant populations.

Conclusions:

  • Accurate assessment of kidney function is essential for managing transplant recipients and improving outcomes.
  • Existing methods for estimating kidney function require careful consideration of their limitations in the transplant context.
  • Further research and validation of kidney function assessment tools are needed for both renal and nonrenal solid organ transplant recipients.