Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Ras Gene

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...

Tumor Progression

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Abnormal Proliferation

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the daughter...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effects of feeding silage inoculated with Lactococcus lactis and Lentilactobacillus buchneri on performance and nutrient utilization in transition dairy cows.

Journal of dairy science·2026

Same author

Recommendations for the implementation of a national lung cancer screening program in Portugal-A consensus statement.

Pulmonology·2024

Same author

Validity of central pain processing biomarkers for predicting the occurrence of oncological chronic pain: a study protocol.

BMC cancer·2024

Same author

Polymorphisms and haplotypes of <i>TOLLIP</i> and <i>MUC5B</i> are associated with susceptibility and survival in patients with fibrotic hypersensitivity pneumonitis.

Pulmonology·2024

Same author

Early detection of interstitial lung disease in rheumatic diseases: A joint statement from the Portuguese Pulmonology Society, the Portuguese Rheumatology Society, and the Portuguese Radiology and Nuclear Medicine Society.

Pulmonology·2023

Same author

Influenza vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Society of Cardiology, the Portuguese Society of Diabetology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Geriatrics and Gerontology, and the Study Group of Geriatrics of the Portuguese Society of Internal Medicine.

Pulmonology·2023

Search research articles

Related Experiment Video

Updated: Jul 13, 2026

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Association between FAS polymorphism and prostate cancer development.

L Lima¹, A Morais, F Lobo

¹Molecular Oncology Unit, Instituto Português de Oncologia, Porto, Portugal.

Prostate Cancer and Prostatic Diseases

|August 2, 2007

Summary

Genetic variations in the FAS gene offer significant protection against prostate cancer, particularly for carriers of the G allele. This finding may reduce soluble Fas levels, preventing apoptosis inhibition in prostate cancer development.

More Related Videos

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Related Experiment Videos

Last Updated: Jul 13, 2026

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Isolation, Culture, and Characterization of Prostate Cancer-Associated Fibroblasts

Published on: August 1, 2025

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Multi-Gene Single Nucleotide Polymorphism Detection in Gastric Cancer Based on Ion Semiconductor Sequencing Platform

Published on: May 10, 2024

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

Published on: December 22, 2020

Area of Science:

Genetics
Oncology
Molecular Biology

Background:

The role of FAS gene polymorphisms in prostate cancer susceptibility and progression remains largely uninvestigated.
FAS (also known as CD95 or APO-1) is a cell surface receptor crucial for regulating apoptosis.
Alternative splicing of the FAS gene produces membrane-bound Fas receptors that induce apoptosis and soluble Fas (sFas) that can inhibit this process.

Purpose of the Study:

To investigate the association between FAS gene polymorphisms, specifically at the -670 locus, and the risk of developing prostate cancer.
To determine if specific FAS genotypes or alleles correlate with protection against prostate cancer, particularly in cases with extra-capsular invasion.

Main Methods:

Utilized the polymerase chain reaction (PCR)-based restriction fragment-length polymorphism (RFLP) technique.
Analyzed DNA samples from a cohort of 904 men, comprising 657 prostate cancer patients and 247 healthy controls.
Calculated odds ratios (OR) and confidence intervals (CI) to assess the statistical significance of genotype and allele associations.

Main Results:

Carriers of the AG or GG genotypes at the FAS gene locus -670 demonstrated statistically significant protection against prostate cancer with extra-capsular invasion (OR=0.30; CI: 0.20-0.44 and OR=0.22; CI: 0.12-0.74, respectively).
Overall, individuals carrying the G allele showed a substantial 72% protection against the disease (OR=0.28; CI: 0.19-0.41).

Conclusions:

The G allele of the FAS gene polymorphism at -670 may confer a protective effect against prostate cancer, especially in advanced stages.
This protective effect might be mediated by a reduction in soluble Fas (sFas) levels, thereby preventing the inhibition of the apoptotic pathway by sFas.