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[FTY720 (Fingolimod) as a new therapeutic option for multiple sclerosis]
J Klatt1, H-P Hartung, R Hohlfeld
1Novartis Pharma GmbH Nürnberg.
Der Nervenarzt
|August 2, 2007
Summary
FTY720 (fingolimod) shows promise as an oral treatment for multiple sclerosis, reducing relapses by over 50% in early trials. Further phase III studies are underway to confirm its efficacy and safety.
Area of Science:
- Neuroimmunology
- Pharmacology
Context:
- Current multiple sclerosis therapies require parenteral administration.
- Oral multiple sclerosis therapeutics are emerging.
Purpose:
- To review the biological effects, animal data, and early clinical findings of FTY720 (fingolimod).
- To highlight FTY720's innovative mechanism targeting multiple sclerosis pathogenesis.
Summary:
- FTY720 (fingolimod) demonstrated a relapse reduction exceeding 50% compared to placebo in a phase II multiple sclerosis trial.
- The drug exhibits an acceptable safety profile in initial human studies.
- FTY720's mechanism of action targets key elements in multiple sclerosis pathogenesis.
Impact:
- FTY720 represents a potential novel oral therapeutic for multiple sclerosis.
- Positive phase II results warrant confirmation in ongoing global phase III trials.
- Successful development could significantly alter multiple sclerosis treatment paradigms.
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