Related Experiment Video
Updated: Jul 13, 2026
Surgical Model for Single-Staged Tissue-Engineered Urothelial Tubes in Minipigs
Published on: July 5, 2024
[Urethroplasty with tissue matrix. Microsurgical animal experiments with small intestinal submucosa]
M Beintker1, B Vogt, J Schubert
1Urologische Klinik, Südharz-Krankenhaus gGmbH, Kochstrasse 39, 99734 Nordhausen. matthiasbeintker@web.de
Background:
The purpose of this study was to examine whether use of small intestinal submucosa in microsurgical urethroplasty in Wistar rats represents an alternative.
Methods:
In 20 Wistar rats microsurgical urethroplasty with small intestinal submucosa was done to repair distal or proximal urethral defects. Four weeks later urethral calibration and urethrography were performed in addition to histological studies.
Results And Conclusions:
Of the 20 animals, 19 survived the observation period without evidence of fistulas, strictures, stenoses, or necroses. The histological results confirmed an intact tissue layer.
