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Severe reaction to 5% imiquimod cream with excellent clinical and cosmetic outcomes
H L Greenberg1, Joel L Cohen, Ted Rosen
1Division of Dermatology, Scott & White Memorial Hospital and Clinic,; Scott, Sherwood and Brindley Foundation, Texas A&M University System Health Science Center, College of Medicine, Temple, TX, USA.
Abstract:
Imiquimod, an immune response modifier approved for the treatment of external genital warts, actinic keratoses, and superficial basal cell carcinoma, can induce a severe local inflammatory response. This phenomenon can accompany inappropriately overzealous, as well as entirely conventional, drug utilization. Despite strikingly brisk reactions, the 9 patients reported herein ultimately experienced excellent cosmetic and clinical outcomes. We report this series to alert clinicians of the good prognosis for a satisfactory outcome even when faced with extreme imiquimod cream-induced inflammation.
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