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Acute Inflammation III: Local and Systemic Effects

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Related Experiment Video

Updated: Jul 13, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Systemic effects of periodontitis.

Bruno G Loos1

  • 1Department of Periodontology, Academic Centre for Dentistry, Amsterdam (ACTA), Amsterdam, The Netherlands.

Annals of the Royal Australasian College of Dental Surgeons
|August 3, 2007
PubMed
Summary

Periodontitis patients show higher systemic inflammation markers like leukocytes and C-reactive protein (CRP). These elevated markers may link gum disease to cardiovascular and cerebrovascular events.

Area of Science:

  • Periodontology
  • Immunology
  • Cardiovascular Medicine

Background:

  • Periodontitis is a chronic inflammatory disease affecting the gums and supporting structures.
  • Systemic inflammation plays a role in various chronic diseases, including cardiovascular conditions.
  • Elevated inflammatory markers are observed in periodontitis, but their systemic implications require further elucidation.

Purpose of the Study:

  • To review and synthesize current knowledge on systemic inflammatory markers in periodontitis.
  • To explore the potential link between periodontitis-associated inflammation and systemic diseases like cardiovascular disease.
  • To investigate the role of bacteremia from periodontal lesions in systemic inflammation.

Main Methods:

  • Literature review of studies investigating systemic inflammatory markers in periodontitis patients versus healthy controls.

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Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

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Last Updated: Jul 13, 2026

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
07:15

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils

Published on: January 21, 2020

Isolation, Processing and Analysis of Murine Gingival Cells
09:47

Isolation, Processing and Analysis of Murine Gingival Cells

Published on: July 2, 2013

  • Analysis of plasma levels and cellular counts of specific inflammatory markers.
  • Examination of epidemiological data linking periodontitis to cardiovascular and cerebrovascular events.

    • Main Results:

    • Consistently higher total leukocyte counts and plasma C-reactive protein (CRP) levels in periodontitis patients compared to healthy individuals.
    • Identified systemic inflammatory markers in periodontitis that are also predictive markers for cardiovascular diseases.
    • Hypothesized that daily bacteremia from periodontal lesions contributes to systemic inflammation.

    Conclusions:

    • Periodontitis is associated with elevated systemic inflammatory markers, including leukocytes and CRP.
    • These systemic inflammatory changes may contribute to the observed association between periodontitis and cardiovascular/cerebrovascular diseases.
    • The size of periodontal lesions may correlate with the extent of systemic inflammation.