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Phase equilibria and stability characteristics of chlorpropamide-urea solid dispersions
The Journal of Pharmacy and Pharmacology
|April 1, 1977
Summary
This study investigated chlorpropamide and urea mixtures using differential scanning calorimetry. The eutectic composition was 89% chlorpropamide, forming solid solutions and glass solids, with ageing affecting crystal size.
Area of Science:
- Pharmaceutical science
- Materials science
Background:
- Chlorpropamide is an antidiabetic drug.
- Urea is a common pharmaceutical excipient.
Purpose of the Study:
- To investigate the phase behavior of chlorpropamide-urea mixtures.
- To understand the impact of composition and ageing on these systems.
Main Methods:
- Preparation of physical mixtures and melts of chlorpropamide and urea.
- Analysis using differential scanning calorimetry (DSC).
Main Results:
- The eutectic composition was determined to be 89% w/w chlorpropamide.
- Solid solutions formed at higher chlorpropamide concentrations (>89%).
- Melts in the 50-100% chlorpropamide range formed glass solids, with ageing increasing liquidus peak temperature due to crystal growth.
Conclusions:
- The phase diagram of chlorpropamide-urea systems was elucidated.
- Ageing influences the thermal properties of these mixtures, likely through crystal size modification.