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The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma
Published on: April 16, 2019
[Toxic epidermal necrolysis induced by phenytoin and whole brain radiotherapy]
F A Fernández1, E Pintor, R Quesada
1Servicio de Medicina Interna, Hospital La Moraleja-Sanitas, Alcobendas, Madrid, España.
Abstract:
Toxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) have been associated with some drugs, particularly anticonvulsants such as phenytoin. Some authors have pointed out an increased risk of TEN/SJS when phenytoin is associated with whole brain radiotherapy. We report a patient diagnosed with breast adenocarcinoma and brain metastases that was on treatment with phenytoin and, shortly after receiving whole brain radiotherapy, developed toxic epidermal necrolysis.
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