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Updated: Jul 13, 2026
Preparation of Peripheral Blood Mononuclear Cell Pellets and Plasma from a Single Blood Draw at Clinical Trial Sites for Biomarker Analysis
Published on: March 20, 2021
[Stakes of pre-analytical parameters in blood transcriptomic and proteomic analysis. Application to clinical
Céline Pangault1, Marie Arlotto, François Berger
1Département HITC, UPRES EA3889, CHU Pontchaillou, 35033 Rennes, France. celine.pangault@univ-rennes1.fr
Abstract:
Numerous parameters related to the patients and the conditions of the sample collection can affect the properties of a biological sample. The pre-analytical parameters are especially important to deal with in the setting of multicenter clinical trials. Here, we report the preliminary results of a trial conducted by the cooperative group GOELAMS (Groupe Ouest-Est des Leucémies aiguës et Autres Maladies du Sang) to define the pre-analytical parameters that affect the proteomic analysis of serum samples in patients with B-cell non Hodgkin lymphoma included in clinical trials.