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Updated: Jul 13, 2026
05:48
Left Coronary Artery Ligation: A Surgical Murine Model of Myocardial Infarction
Published on: August 9, 2022
Post myocardial infarction left ventricular free wall rupture.
Pankaj Kumar Mishra1, Vivek Pathi, Andrew Murday
1Department of Cardiothoracic Surgery, Glasgow Royal Infirmary, 16 Alexandra Parade, Glasgow, UK. mishrapk_25@yahoo.com
Interactive Cardiovascular and Thoracic Surgery
|August 3, 2007
Summary
Left ventricular free wall rupture after myocardial infarction is deadly. Early diagnosis and surgery improve survival, with repair tailored to tear status.
Area of Science:
- Cardiology
- Cardiac Surgery
Background:
- Left ventricular free wall rupture (LVFWR) is a rare but fatal complication of myocardial infarction.
- Management strategies for LVFWR are debated, contributing to high mortality rates.
Purpose of the Study:
- To review the institute's experience with LVFWR surgical management.
- To discuss optimal treatment strategies based on a literature review.
Main Methods:
- Retrospective review of six LVFWR patients treated over ten years.
- Surgical repair using cardiopulmonary bypass.
- Literature review on management strategies.
Main Results:
- All six patients underwent surgery with cardiopulmonary bypass and intra-aortic balloon pump support.
- Two patients died post-operatively.
- No neurological deficits were observed in surviving patients.
Conclusions:
- Early diagnosis and prompt surgical intervention are crucial for improving survival.
- Surgical repair should be individualized based on the specific characteristics of the tear.
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