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Related Concept Videos

Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
Candidiasis01:20

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...

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Related Experiment Video

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Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients
05:26

Examination of Oral Candida Infection in Primary Sjögren's Syndrome Patients

Published on: March 1, 2024

Native-valve endocarditis due to Candida parapsilosis.

Chung-Dann Kan1, Chwan-Yau Luo, Pao-Yen Lin

  • 1Department of Surgery, Division of Cardiovascular Surgery, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan. kcd@pchome.com.tw

Interactive Cardiovascular and Thoracic Surgery
|August 3, 2007
PubMed
Summary

This case study highlights a rare instance of Candida parapsilosis native-valve endocarditis. Prompt surgical intervention and antifungal therapy led to a successful outcome, suggesting a viable treatment approach for this severe infection.

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Area of Science:

  • Cardiology
  • Infectious Diseases
  • Mycology

Background:

  • Candida parapsilosis endocarditis carries a high mortality rate.
  • Native-valve endocarditis due to C. parapsilosis is uncommon, typically seen in specific patient populations.
  • This report details a rare case of native-valve endocarditis involving multiple valves.

Purpose of the Study:

  • To report a successful management of a rare case of Candida parapsilosis native-valve endocarditis.
  • To evaluate the efficacy of combined surgical and antifungal treatment.
  • To emphasize the importance of long-term follow-up in such cases.

Main Methods:

  • A case of aortic and mitral valve endocarditis caused by Candida parapsilosis was described.
  • The patient underwent prompt double-valve replacement surgery.
  • Treatment included intravenous amphotericin B and fluconazole, followed by oral antifungal medication.

Main Results:

  • The patient survived the complex surgery and achieved a positive outcome.
  • No recurrent symptoms were observed five years post-surgery.
  • The combined therapeutic strategy proved effective in this case.

Conclusions:

  • Prompt valve replacement surgery combined with appropriate antifungal therapy (amphotericin B and fluconazole) can be adequate for Candida parapsilosis native-valve endocarditis.
  • A 6-month course of oral antifungal medication may be sufficient.
  • Lifelong regular echocardiographic follow-up is essential to monitor for recurrence.