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Native-valve endocarditis due to Candida parapsilosis

Chung-Dann Kan1, Chwan-Yau Luo, Pao-Yen Lin

  • 1Department of Surgery, Division of Cardiovascular Surgery, National Cheng Kung University Hospital, 138 Sheng-Li Road, Tainan 704, Taiwan. kcd@pchome.com.tw

Interactive Cardiovascular and Thoracic Surgery
|August 3, 2007
PubMed

Insights

This case study highlights a rare instance of Candida parapsilosis native-valve endocarditis. Prompt surgical intervention and antifungal therapy led to a successful outcome, suggesting a viable treatment approach for this severe infection.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Mycology

Background:

  • Candida parapsilosis endocarditis carries a high mortality rate.
  • Native-valve endocarditis due to C. parapsilosis is uncommon, typically seen in specific patient populations.
  • This report details a rare case of native-valve endocarditis involving multiple valves.

Purpose of the Study:

  • To report a successful management of a rare case of Candida parapsilosis native-valve endocarditis.
  • To evaluate the efficacy of combined surgical and antifungal treatment.
  • To emphasize the importance of long-term follow-up in such cases.

Main Methods:

  • A case of aortic and mitral valve endocarditis caused by Candida parapsilosis was described.
  • The patient underwent prompt double-valve replacement surgery.
  • Treatment included intravenous amphotericin B and fluconazole, followed by oral antifungal medication.

Main Results:

  • The patient survived the complex surgery and achieved a positive outcome.
  • No recurrent symptoms were observed five years post-surgery.
  • The combined therapeutic strategy proved effective in this case.

Conclusions:

  • Prompt valve replacement surgery combined with appropriate antifungal therapy (amphotericin B and fluconazole) can be adequate for Candida parapsilosis native-valve endocarditis.
  • A 6-month course of oral antifungal medication may be sufficient.
  • Lifelong regular echocardiographic follow-up is essential to monitor for recurrence.

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