Related Experiment Video
Updated: Jul 13, 2026

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
Published on: June 14, 2015
Surgical glue resembling left atrial thrombus
S Nicholas Fletcher1, Kaushik Mandal, Marjan Jahangiri
1Department of Anesthesia, St George's Hospital and Medical School, Blackshaw Road, London SW17 0QT, UK.
Surgical glue during aortic root replacement in a patient with Down syndrome caused an unusual inversion of the left atrial appendage. This created a false appearance of a left atrial mass, a rare surgical complication.
Area of Science:
- Cardiology
- Cardiac Surgery
- Medical Imaging
Background:
- Severe aortic regurgitation necessitates complex surgical intervention.
- Down syndrome presents unique challenges in cardiovascular surgery.
- Left atrial appendage inversion is a rare but significant surgical complication.
Purpose of the Study:
- To report a rare case of left atrial appendage inversion due to surgical glue.
- To highlight the diagnostic challenges posed by this complication.
- To discuss the implications for intraoperative and postoperative management.
Main Methods:
- Case report of a 41-year-old female with Down syndrome and severe aortic regurgitation.
- Description of homograft aortic root replacement procedure.
- Observation of left atrial appendage inversion following surgical glue application.
Main Results:
- Surgical glue application led to the inversion of the left atrial appendage.
- The inverted appendage mimicked a left atrial mass on imaging.
- This created a diagnostic dilemma during the surgical procedure.
Conclusions:
- Surgical glue can cause unexpected anatomical distortions.
- Careful intraoperative assessment is crucial to differentiate true pathology from iatrogenic changes.
- Awareness of such rare complications is important for cardiac surgeons.
More Related Videos
08:40TAPE: A Biodegradable Hemostatic Glue Inspired by a Ubiquitous Compound in Plants for Surgical Application
Published on: June 8, 2016
08:05Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022