Mitochondrial mutations are a late event in the progression of head and neck squamous cell cancer

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Transmitochondrial Cybrid Generation Using Cancer Cell Lines
07:49

Transmitochondrial Cybrid Generation Using Cancer Cell Lines

Published on: March 17, 2023

Suhail K Mithani1, Janis M Taube, Shaoyu Zhou

  • 1Division of Plastic and Reconstructive Surgery, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287-0910, USA.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research
|August 3, 2007
PubMed
Abstract

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Mutations01:39

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Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...