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Updated: Jul 13, 2026

Pull-down of Calmodulin-binding Proteins
Published on: January 23, 2012
A structural insight into lead neurotoxicity and calmodulin activation by heavy metals
1Department of Biochemistry, University of Oulu, Oulu, Finland. petri.kursula@oulu.fi
Abstract:
Calmodulin is a calcium sensor that is also capable of binding and being activated by other metal ions. Of specific interest in this respect is lead, which is known to be neurotoxic and to have a very high affinity towards calmodulin. Crystal structures of human calmodulin complexed with lead and barium ions have been solved. The results will help in understanding the activation mechanisms of calmodulin by different heavy metals and will provide a detailed view of a putative target for lead neurotoxicity in humans.
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