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Updated: Jul 13, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
Targeting the hedgehog pathway to mitigate treatment resistance
Yu-Jen Chen1, Jennifer Sims-Mourtada, Julie Izzo
1Department of Radiation Oncology, MD Anderson Cancer Center, Houston, Texas 77030, USA.
Abstract:
'Hedgehog' (HH) molecules are secretory signaling proteins that were first discovered in Drosophila. Three HH homologs have been identified in humans including Sonic hedgehog (SHH), Indian hedgehog (IHH) and Desert hedgehog (DHH). During embryonic development, the Hedgehog (HH) signaling pathway is critical, and it regulates both proliferation and differentiation of various types of stem cells.1This article provides a brief overview of HH signaling, summarizes the correlation between HH signaling and treatment resistance of cancer cells, and discusses the recent advances in targeting this signaling cascade to overcome treatment resistance with supporting experimental results.
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