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Related Experiment Video

Updated: Jul 13, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

Published on: October 30, 2013

Evolution of the human MUC1 oncoprotein.

Sekhar Duraisamy¹, Turner Kufe, Selvi Ramasamy

¹Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

International Journal of Oncology

|August 3, 2007

Summary

The transmembrane mucin 1 (MUC1) oncogenic function originated from secreted mucins. MUC1 subunits evolved from MUC5B, with the cytoplasmic domain diversifying to gain transforming abilities.

Area of Science:

Molecular Biology
Cancer Research
Evolutionary Biology

Background:

The mucin (MUC) family includes secreted and membrane-bound forms.
Transmembrane mucin 1 (MUC1) is overexpressed in various human carcinomas and hematologic malignancies.
MUC1 subunits (MUC1-N and MUC1-C) arise from autocleavage within the SEA domain.

Purpose of the Study:

To investigate the evolutionary origin of the MUC1 cytoplasmic domain (MUC1-CD) and its associated transforming sequences.
To determine the ancestral relationship between MUC1 and other mucin family members.

Main Methods:

Comparative sequence analysis of MUC1 with other mucins.
Phylogenetic analysis to trace evolutionary pathways.

Main Results:

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Last Updated: Jul 13, 2026

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development

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Published on: October 30, 2013

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins

Mucin Agarose Gel Electrophoresis: Western Blotting for High-molecular-weight Glycoproteins

Published on: June 14, 2016

MUC1-CD sequences evolved from repeat regions within the secreted mucin MUC5B.
Sequences upstream of the MUC1 SEA domain also originated from MUC5B.
MUC1 subunits evolved from secreted gel-forming mucins, with MUC1-CD gaining oncogenic function through diversification.

Conclusions:

MUC1 evolved from secreted mucins, specifically MUC5B.
The oncogenic potential of MUC1-CD is a result of evolutionary diversification after its origin from MUC5B.
Understanding MUC1 evolution provides insights into cancer development.