Related Experiment Video

Updated: Jul 13, 2026

Assessing Respiratory Immune Responses to Haemophilus Influenzae
06:32

Assessing Respiratory Immune Responses to Haemophilus Influenzae

Published on: June 29, 2021

[Effect of vaccination against pneumococcal infection and influenza in children with asthma]

N P Andreeva, T I Petrova, O I Golubtsova

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |August 4, 2007
    PubMed

    Insights

    Pneumococcal and influenza vaccines reduced asthma exacerbations in children. Immunization increased IgG levels without raising IgE, indicating safety and efficacy in managing childhood asthma.

    Area of Science:

    • Pediatric Allergy and Immunology
    • Vaccinology
    • Respiratory Medicine

    Background:

    • Asthma exacerbations significantly impact children's quality of life.
    • Pneumococcal and influenza infections can trigger asthma exacerbations.
    • The role of vaccination in managing pediatric asthma requires further investigation.

    Purpose of the Study:

    • To assess the clinical course of asthma in children following immunization.
    • To evaluate the IgG response to pneumococcal vaccination in children with asthma.
    • To determine if combined pneumococcal and influenza vaccination impacts asthma exacerbations.

    Main Methods:

    • A study involving 78 children (aged 4-17) with asthma.
    • Two groups were formed: one received pneumococcal and influenza vaccines, the other only pneumococcal vaccine.
    • Clinical course (asthma exacerbations) and IgG levels were monitored post-vaccination.

    Main Results:

    • Asthma exacerbations decreased by 1.7 times in the combined vaccine group and 1.5 times in the pneumococcal-only group.
    • Increased IgG levels to pneumococcal antigens were observed in both vaccinated groups.
    • No significant increase in IgE levels was detected, suggesting no allergic sensitization.

    Conclusions:

    • Immunization against pneumococcal infection, alone or combined with influenza, reduces asthma exacerbations in children.
    • Vaccination leads to protective immunity against Streptococcus pneumoniae without causing sensitization.
    • Pneumococcal and influenza vaccines are safe and effective adjuncts in managing pediatric asthma.

    More Related Videos

    Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels05:31

    Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

    Published on: August 7, 2017

    Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria11:32

    Following in Real Time the Impact of Pneumococcal Virulence Factors in an Acute Mouse Pneumonia Model Using Bioluminescent Bacteria

    Published on: February 23, 2014

    Related Concept Videos

    Asthma I: Introduction01:28

    Asthma I: Introduction

    Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
    Vaccinations01:51

    Vaccinations

    Overview
    Asthma-III: Symptoms and Complications01:24

    Asthma-III: Symptoms and Complications

    Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
    Classification of Asthma
    Asthma-IV: Diagnostic and Management01:30

    Asthma-IV: Diagnostic and Management

    The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
    Clinical Assessment for Asthma:
    This is the first step in diagnosing and managing asthma. It includes:
    Asthma: Pathogenesis and Management01:20

    Asthma: Pathogenesis and Management

    Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
    Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
    Asthma III: Clinical Manifestations01:13

    Asthma III: Clinical Manifestations

    Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...